The Dumping Grounds

December 8, 2016 | No Comments » | Topics: The Dumping Grounds |

funny pictures and videos of the day

funny pictures and videos of the day

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Hot Girls With Meat On Their Bones

December 8, 2016 | 9 Comments » | Topics: Compilation |


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This One Goes Out To All My Jiu Jitsu Loving Brethren

December 8, 2016 | No Comments » | Topics: Sports |

jiu jitsu

Marcelo’s Jiu Jitsu Wizardry!

 

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There Are Some Things You Just Can’t Argue With

December 8, 2016 | No Comments » | Topics: Funny Pictures |

 

funny pictures that are just too true

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Hot Instagram Babe Of The Day: Jessica Clements

December 8, 2016 | 1 Comment » | Topics: Babes |

hot instagram babe of the day Jessica Clements

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Awesome Stuff Around The Internet

December 7, 2016 | No Comments » | Topics: main |

50+ Of The Best Images Of The Year Announced By National Geographic – Bored Panda

Ashley Graham Wants to See Plus-Size Models on the Victoria’s Secret Runway – Maxim

Tesla Just Powered a 600-Person Island With Energy – Leenks

Apple has made over $600 million off US taxpayers since 2012 by avoiding taxes — here’s how – Rare

Former boxing champ KO’d a young punk for mouthing off – Faves

The Creepiest Things Little Kids Have Ever Said – Ranker

Google Says It Will Run Entirely on Renewable Energy in 2017 – Newser

10 Historical Facts That Will Make You Think Twice About Romanticizing The Past – Mandatory

Donald Trump Is Time Magazine’s Person Of The Year – Bossip

Barbara Palvin…Dayuuuum! – Hollywood Tuna

This Tiny Dog Rides On Top of Her Giant St. Bernard Big Brother Everywhere They Go – 22 Words

Maisie Williams & Sophie Turner(?) Were in Thongs – G-Celeb

Smile, It’s Hump Day! – Radass

34 Insta-Hot Pics of Monica Alvarez – Regretful Morning

Hollywood’s Most Overpaid Actors According To Forbes – The Blemish

God bless the genius who invented yoga pants (32 Photos) – Bad Sentinel

Sixteen Awesome Swords of the ’80s – Gunaxin

24 things to consider before taking Adderall – Business Insider

Wouldn’t you love to come home from a long day at work to this – Ehowa


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The Dumping Grounds

December 7, 2016 | No Comments » | Topics: The Dumping Grounds |

funny pictures and videos of the day

funny pictures and videos of the day

Read the rest of this entry »


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A Few Answers To Questions You Always Wondered About

December 7, 2016 | No Comments » | Topics: Answers, Interesting |

Why are drug prices so high?

Drug development is the most high risk/high reward industry possible. It costs roughly 2 billion USD to take a drug from conception to market. The vast majority of drugs never make it to market. Each of those failures costs some fraction of 2 billion USD. Many of those failures are weeded out only at the end when all of that investment has already been made. For those failures, the company makes back 0 of it’s investment. It’s not like a phone that doesn’t sell as spectacularly well as hoped. It’s no product at all. You can’t even learn much from those failures. It’s years of people lives (sometimes 10 or more) and huge amounts of money that just evaporate. It’s crushing.

This is why the drugs that work have to be expensive. They have to pay the company back and more for all the failures. Interestingly, most companies making drugs aren’t huge. Most are quite small:

Here’s an anecdote that represents a typical trajectory of a drug in development. It’s an entirely true story but the numbers are best approximations:

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